Lupus Science & Medicine® is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. An official journal of the Lupus Foundation of America (LFA), which is dedicated to advancing the science and medicine of lupus while offering support to ...

Oct 29, 2023 · Objective Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterised by venous thrombosis (VT) or arterial thrombosis (AT) and/or pregnancy morbidity and the presence of antiphospholipid antibodies. Direct oral anticoagulants (DOACs) hold several advantages to vitamin K antagonists (VKAs) for prevention of thrombosis and we wish to evaluate DOACs compared with VKAs in ...

Sep 27, 2022 · Purpose Activation of toll-like receptor (TLR)7/8 by self-RNA induces production of type I interferon and several other proinflammatory cytokines, which may contribute to the pathophysiology of SLE and other related autoimmune diseases. Afimetoran, a potent, selective, oral small-molecule inhibitor of TLR7/8, was developed for potential treatment of autoimmune diseases and has shown robust ...

A lupus journal publishing basic, clinical, translational and epidemiological studies on all aspects of lupus and related diseases. An official journal of Lupus Foundation of America.

AdelhelmfiBH, etfial Lupus Science Medicine 202310e001018 doi101136lupus2023001018 1 Therapy with direct oral anticoagulants for secondary prevention of thromboembolic events in the antiphospholipid syndrome: a systematic review and meta-analysis of

Sep 4, 2019 · Macrophage activation syndrome (MAS) is a life-threatening hyper-inflammatory syndrome characterised by excessive activation and proliferation of T lymphocytes and macrophages and a consequent massive production of cytokines, or ‘cytokine storm’. MAS is considered a secondary or acquired form of haemophagocytic lymphohistiocytosis (HLH) and is usually associated with infection (systemic ...

Sep 5, 2024 · Hemophagocytic lymphohistiocytosis (HLH) is a well-recognised complication of systemic lupus erythematosus (SLE). In one small case series, HLH was noted in approximately 5% of patients with lupus. 1 Differentiating lupus flare from HLH can be challenging, since both can cause fever and cytopenia. A recent review of published literature included studies that combined information about a total ...

van VollenhovenflRF, etfial Lupus Science Medicine 20218e000538 doi101136lupus-2021-000538 1 2021 DORIS definition of remission in SLE: final recommendations from an international task force Ronald F van Vollenhoven ,1 George Bertsias,2 Andrea Doria ,3 David Isenberg,4 Eric Morand ,5 Michelle A Petri ,6 Bernardo A Pons-Estel ,7 Anisur Rahman,8 Manuel Francisco Ugarte-Gil ,9,10

Feltenr, etfial.Lupus Science Medicine 20196e000303. doi10.1136lupus2018000303 1 10 most important contemporary challenges in the management of SLE Renaud Felten,1,2 Flora Sagez,1,2 Pierre-Edouard Gavand,2,3 Thierry Martin,2,3 Anne-Sophie Korganow,2,3 Christelle Sordet,1,2 Rose-Marie Javier,1,2 Pauline Soulas-Sprauel,2,3 Marianne Rivière,4 Florence Scher,5 Vincent Poindron,2,3

Jan 2, 2022 · We aimed to conduct a systematic review and meta-analysis of studies on central nervous system (CNS) infections in patients with SLE, in order to describe their clinical and microbiological characteristics, and outcomes. A systematic search of PubMed/Medline and Embase electronic databases was performed (March 2021) to identify all published studies on CNS infections and their characteristics ...