Here, integrating ribosome profiling, RNA-seq and proteomics to reveal transcriptional and post-translational regulation in HIV-infected T cells, the authors show that non-AUG translation of viral ...

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2006). However, careful analysis of sEV pellets in iodixanol gradients revealed the presence of a distinct non-vesicular fraction (NVF) enriched with metabolic enzymes (GAPDH, PKM, ENO1), cytoplasmic ...

In addition, the cascades or series of molecular responses that cells show are just beginning to be understood. Notably, the ribosome, a ribonucleoprotein complex that is essential for translation on ...

Here, we adapt a classic approach of polysome profiling coupled with global gene expression ... We observe frequent intron retention on ribosome-associated transcripts, even in high-polysome fractions ...

Using a new bioinformatic method to analyze ribosome profiling data, we show that 40% of lncRNAs and pseudogene RNAs expressed in human cells are translated. In addition, ~35% of mRNA coding genes are ...