High resolution crystal structures of SF1 enzymes in complex with DNA and various nucleotide ... and hydrolysis of nucleoside triphosphates, helicases move along nucleic acid filaments and ...

Sol. In nucleoside, base is attached to sugar at position. On the other hand, in a nucleotide, all the three basic components ...

The Nucleic Acids Institute is dedicated to understanding the chemical and biological basis for nucleic acid function, and to developing new and powerful nucleic acids based therapeutic and ...

The NTP and dNTP hydrolysis reactions were performed in a reaction mixture consisting of 50 mM Tris–HCl (pH 8.0), 250 mM KCl, 2 mM MgCl 2, 2 mM DTT, 1 μM DDX1, and 1 mM nucleotide or ... different ...

Notably, IDEA learns the interaction matrix between each amino acid and nucleotide, allowing for direct interpretation of the “molecular grammar” governing the binding specificities of DNA binding ...

The tryptic peptides were acidified to pH 3 with 10% formic acid and desalted using hand-packed stage tips of C18 resin. The peptides were eluted with 80% acetonitrile and 0.1% formic acid and were ...

Laboratoire de Biologie et Modélisation de la Cellule, CNRS, UMR 5239, Inserm, U1293, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon, France Centre ...

To date, there are no approved commercially available vaccines, and anti-HSV-1 drugs such as specific or non-specific nucleotide (nucleoside) analogs and helicase-primase inhibitors have become the ...

Together with new in vitro HBV infection systems, based on the identification of the bile acid transporter sodium taurocholate cotransporting polypeptide as an HBV entry receptor, this offers novel ...

Celery, a key vegetable in the Apiaceae family, is widely valued for its nutrition and medicinal uses. It is commonly categorized into three varieties: A. graveolens var. dulce (common celery ...