At 7-9 on the season, a win against Jacksonville in Week 18 could see the Colts stay put at their current draft slot or even drop a few selections. A loss, however, and they could move up a spot or two depending on what else happens around the NFL.

The Jacksonville Jaguars (4-12) are 4.5-point underdogs in a road AFC South matchup against the Indianapolis Colts (7-9) on Sunday, January 5, 2025 at Lucas Oil Stadium.NFL odds courtesy of BetMGM

Strangely, vibes are much better on the sidelines of the 4-12 team than the one at 7-9. While a loss is better for the Jaguars' chances at getting a top-five pick — even the first pick is still an outside shot — they are not playing with that mentality. Even if the Colts sneak out a victory here, it will not be by more than five points.

NFL Week 18 odds, picks, predictions, TV channel, streaming information for Sunday football game between Jacksonville Jaguars and Indianapolis Colts.