This inhibition resulted in a significant reduction ... "With the potential to be used as a nucleic acid-based therapeutic, iSN40 could become an essential tool in addressing the growing ...

5) and to study its enzymatic properties, and soon thereafter, Miguel Ondetti and I began a fruitful collaborative effort to discover or design potent and specific inhibitors of ACE. The modern ...

Target identification is the process of identifying the direct molecular target – for example protein or nucleic acid – of a small ... highly selective kinase inhibitors remains challenging.