It’s Louisville Cardinals vs Creighton Bluejays to begin March Madness. Here’s our prediction for the 2025 NCAA Tournament basketball game.

UofL was placed in the South Region, and their first and second round games will be played at Rupp Arena in Lexington, Ky. They're matched up against No. 1 Auburn vs. No. 16 Alabama State/St. Francis, with the top four teams in the region being Auburn, Iowa State, Michigan State and Texas A&M.