Lionel Messi, Julián Alvarez and Lautaro Martínez all started for the World Cup holders as they were stunned at Estadio Defensores del Chaco.

World champions Argentina suffered a 2-1 defeat to Paraguay while rivals Brazil were held to a 1-1 draw at Venezuela as South America's big guns struggled in CONMEBOL World Cup qualifying on Thursday.

Argentina are back in action on Thursday with a trip to Asuncion to face a tough Paraguay test with a chance to inch closer to a FIFA 2026 World Cup berth. Lionel Messi and company saw off Bolivia last time out with a hat trick plus two assists in a thumping.

Lionel Messi failed to score as Argentina were beaten 2-1 by Paraguay in CONMEBOL World Cup Qualifiers. The two goals of Paraguay also included an incredible bicycle kick from Antonio Sanabria.

Lionel Messis Argentina Fall to Paraguay in CONMEBOL World Cup Qualifiers, Brazil Held by Venezuela on Frustrating Thursday (November 14) for South American big guns.

Lionel Messi was held scoreless as Argentina suffered a 2-1 loss to Paraguay in a 2026 World Cup qualifying match on Thursday night.

World Cup qualifying leaders Argentina face a tricky trip to face Paraguay in Asuncion on Thursday night. Lionel Scaloni’s side are on the verge of securing qualification to the 2026 World Cup in North America, where they will defend the title they won in Qatar in 2022.

Paraguay will face Argentina in a Matchday 11 clash of the CONMEBOL World Cup Qualifiers. Here's how to watch the game live, either on TV or through streaming platforms available in the USA.

Argentina pays a visit to the Estadio Defensores del Chaco to square up against Paraguay in the first of the two CONMEBOL World Cup qualifier games it'll play to close out 2024's international action.